簡介：鹽酸蒽丹西酮二水合物，Ondansetron鹽酸鹽是5-HT3受體拮抗劑，可作為化療后止吐劑。
鹽酸蒽丹西酮二水合物物理化學性質(zhì)：
|
密度 |
1.27g/cm3 |
|
沸點 |
546oC at 760mmHg |
|
熔點 |
178.5-179.5oC |
|
分子式 |
C18H20ClN3O |
|
分子量 |
329.824 |
|
閃點 |
284oC |
|
精確質(zhì)量 |
329.129486 |
|
PSA |
39.82 |
|
LogP |
3.9305 |
|
外觀性狀 |
白色粉末 |
|
儲存條件 |
?20°C |
|
水溶解性 |
H2O: >5 mg/mL |
鹽酸蒽丹西酮二水合物詳細介紹：
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中文名稱： |
鹽酸蒽丹西酮二水合物 |
|
中文別名： |
鹽酸蒽丹西酮二水合物;N-叔丁氧羰基-L-谷氨酸 1-甲酯;帕羅西汀雜質(zhì)A;鹽酸昂丹可瓊;鹽酸昂丹司瓊;鹽酸昂丹司酮 |
|
英文名稱： |
4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,hydrochloride (1:1) |
|
英文別名： |
4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,hydrochloride (1:1);Ondansetron Hydrochloride;4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,hydrochlo...;Ondansetron (hydrochloride);ONDANSETRON HCL;Ondansetron Hydrochl;Ondansetron hydrochloride dihydrate;1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride;GR 38032;LSUREMONOETHANOLAMID;N-(Hydroxyethyl)oleamide;NSC 665799;ODANSETRON HYDROCHLORIDE DIHYDRATE;OEA;OEA,oleoylethanolamide;oleic acid-N-monoetha;Oleyl monoethanolamide;Ondansetron HCl (Zofran);Ondansetron hydrochloride (Zofran);SN 307 |
|
CAS號： |
99614-01-4 |
|
分子式： |
C18H19N3O.CLH |
|
分子量： |
329.82 |
|
詳細描述： |
博飛美科提供99614-01-4，鹽酸蒽丹西酮二水合物，Ondansetron HCl，Perfemiker，上?，F(xiàn)貨。 Perfemiker，致力于提供高品質(zhì)、高性價比小分子化合物的產(chǎn)品。 Perfemiker小分子化合物大量庫存，提供超過2萬種的抑制劑、激動劑、拮抗劑等產(chǎn)品，是藥物及疾病研究的重要原料供應商。 5-HT3受體拮抗劑，Ondansetron鹽酸鹽是5-HT3受體拮抗劑，可作為化療后止吐劑。 查詢關鍵詞:“99614-01-4，鹽酸蒽丹西酮二水合物，Ondansetron HCl，Perfemiker，上?，F(xiàn)貨”。 |
鹽酸蒽丹西酮二水合物參考文獻：
[1]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.
[2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.
[3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.
[4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.
[5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.
[6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.
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